Tylenol's Impact on Glutathione and Liver Damage What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Acetaminophen Toxicity in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Consultant360 Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.