The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation The Biomics Carnitine shuttle system for transporting fatty acyl CoA into the mitochondrial matrix. The path of the acyl group is traced in red. #biochemistry #biochem #biochimica #biochimie #bioquimica #biochemie #biolchem # Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non cell autonomous manner: Cell Reports Carnitine metabolic disorders and novel clinical approaches: Mechanistic insights from deficiency management to liver and kidney disease treatment ScienceDirect L Carnitine for Fat Loss Supplements in Review