The MTHFR gene mutation is the world's biggest translation problem. If you're born with it, your body can't understand the language of standard vitamins. Even if you ingest them, they'll pass through, MTHFR Autism: The Role of MTHFR and COMT Dr. Michael Veselak, D.C., CFMP MTHFR Gene and Glutathione Connection Explained Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.