3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Acetaminophen & the kidney Renal Fellow Network GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram