Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Nutritional and Hormonal Regulation of Citrate and Carnitine Acylcarnitine Transporters: Two Mitochondrial Carriers Involved in Fatty Acid Metabolism Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L carnitine Translational Research L Carnitine helps shuttle fatty acids into the mitochondria (the power plants of your cells) where they can be burned for energy. It's often used in fat metabolism and energy support formulas. The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation