Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Understanding Lip Spot Causes and Treatments Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Pigmented Lesions of the Oral Mucosa Pocket Dentistry Mucosal melanocytic macules Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in