Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Glutathione recycling and its importance in detoxification g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Reaching for Tylenol when baby is fussy? Here's some information worth knowing. A baby's liver isn't fully mature until around 2 years old Meaning their ability to process certain substances is still