Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy Enzymes of glycolysis and the pentose phosphate pathway as targets of oxidants: Role of redox reactions on the carbohydrate catabolism ScienceDirect Pentose phosphate pathway drives vascular maturation Nature Metabolism Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Glucose metabolism begins with its transport into cells via GLUT transporters, where it is phosphorylated to glucose 6 phosphate (Glucose 6 P). This molecule can enter various pathways, including the pentose phosphate pathway or hexosamine biosynthesis. PENTOSE PHOSPHATE PATHWAY