Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome What Caused These Multiple Hyperpigmented Macules of the Mouth? Labial Macules: Dark Spots on the Lip Dermatology Advisor Pigmented macular lip lesion Clinical Advisor